Johnson K A, Powers B E, Withrow S J, Sheetz M J, Curtis C R, Wrigley R H
Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins.
J Vet Intern Med. 1989 Jul-Sep;3(3):160-6. doi: 10.1111/j.1939-1676.1989.tb03092.x.
Splenomegaly confirmed by surgery or necropsy in 100 dogs was diagnosed histologically as benign neoplasia (n = 1), primary splenic malignancy (n = 59), neoplastic metastases (n = 6), and nonneoplastic disease (n = 34). Dogs with known systemic disease, such as lymphoma and mast cell tumor, that caused splenomegaly were not included in the study. Hemangiosarcoma was the most common splenic disease (43 cases). Overall mean age of the dogs was 10.7 years, the most common breed was German Shepherd dog, and 72 of the dogs weighed more than 21 kg. Dogs with anemia, nucleated red blood cells, abnormal red blood cell morphology, or splenic rupture had a significantly greater chance of having splenic neoplasia (P less than 0.002). A multivariable logistic regression analysis found that the presence of anemia and splenic rupture in dogs with splenomegaly was up to 69% accurate in predicting presence of splenic neoplasia. After splenectomy, the median survival time of dogs with splenic neoplasia was 13 weeks. For dogs with nonneoplastic splenomegaly it was at least 36 weeks.
通过手术或尸检确诊的100只犬脾脏肿大，经组织学诊断为良性肿瘤（n = 1）、原发性脾脏恶性肿瘤（n = 59）、肿瘤转移（n = 6）和非肿瘤性疾病（n = 34）。已知患有导致脾脏肿大的全身性疾病（如淋巴瘤和肥大细胞瘤）的犬未纳入本研究。血管肉瘤是最常见的脾脏疾病（43例）。犬的总体平均年龄为10.7岁，最常见的品种是德国牧羊犬，72只犬体重超过21千克。患有贫血、有核红细胞、红细胞形态异常或脾破裂的犬患脾脏肿瘤的可能性显著更高（P小于0.002）。多变量逻辑回归分析发现，脾脏肿大犬出现贫血和脾破裂对预测脾脏肿瘤的存在准确率高达69%。脾切除术后，脾脏肿瘤犬的中位生存时间为13周。非肿瘤性脾脏肿大犬的中位生存时间至少为36周。
