幽门螺杆菌体外刺激下低度B细胞胃黏膜相关淋巴组织型淋巴瘤中TH1和TH2细胞因子产生情况的分析
Analysis of TH1 and TH2 cytokine production in low grade B cell gastric MALT-type lymphomas stimulated in vitro with Helicobacter pylori.
作者信息
Hauer A C, Finn T M, MacDonald T T, Spencer J, Isaacson P G
机构信息
Department of Paediatric Gastroenterology, St Bartholomew's School of Medicine, St Bartholomew's Hospital, London, UK.
出版信息
J Clin Pathol. 1997 Nov;50(11):957-9. doi: 10.1136/jcp.50.11.957.
Abstract
Previous studies have suggested that the dependence of low grade B cell gastric lymphoma on infection of the gastric mucosa with Helicobacter pylori results from help provided by H pylori specific tumour infiltrating T cells. ELISPOT analysis was used to characterise functional subpopulations of tumour infiltrating T cells. The production of the TH1 cytokine interferon gamma and TH2 cytokines interleukin (IL)-4, IL-5, and IL-10 were measured in tumour cell suspensions from two cases of low grade B cell gastric lymphoma, one case of thyroid gland lymphoma, and one case of salivary gland lymphoma. Cells were assayed on day 0 and following 24 hours incubation either in culture medium or with a range of strains of H pylori. There was a dominant TH1-type (pro-inflammatory) response consistent with the TH1 response observed in H pylori gastritis.
摘要
先前的研究表明，低级别B细胞胃淋巴瘤对胃黏膜感染幽门螺杆菌的依赖性源于幽门螺杆菌特异性肿瘤浸润T细胞提供的辅助作用。采用酶联免疫斑点分析（ELISPOT分析）来鉴定肿瘤浸润T细胞的功能亚群。在两例低级别B细胞胃淋巴瘤、一例甲状腺淋巴瘤和一例涎腺淋巴瘤的肿瘤细胞悬液中，检测了TH1细胞因子干扰素γ以及TH2细胞因子白细胞介素（IL）-4、IL-5和IL-10的产生情况。在第0天以及在培养基中或与一系列幽门螺杆菌菌株一起孵育24小时后，对细胞进行检测。观察到一种占主导地位的TH1型（促炎性）反应，这与在幽门螺杆菌胃炎中观察到的TH1反应一致。
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