Halperin R, Hadas E, Shinar N, Kraicer P F, Schneider D
Department of Obstetrics and Gynecology, Assaf Harofeh Medical Center, Zerifin, Israel.
J Reprod Fertil. 1997 Nov;111(2):243-7. doi: 10.1530/jrf.0.1110243.
The possibility of using the rat as an experimental model for the further research of human decidua-associated protein (hDP) 200 was examined. A rat protein similar to the hDP 200 was identified and immunoaffinity purified, using a monoclonal antibody recognizing hDP 200. The protein was named rat decidua-associated protein (rDP) 200. The abundance of rDP 200 in endometrial tissue extracts and in uterine washings was measured throughout the oestrous cycle and on consecutive days, starting the day after the rats mated until the day after the blastocyst implantation. The results indicate that the highest concentration of rDP 200 in uterine washings may be related to oestrogen control and probably to the implantation process. Further studies are needed to confirm these findings.
研究了将大鼠用作进一步研究人蜕膜相关蛋白（hDP）200的实验模型的可能性。使用识别hDP 200的单克隆抗体，鉴定并免疫亲和纯化了一种与hDP 200相似的大鼠蛋白。该蛋白被命名为大鼠蜕膜相关蛋白（rDP）200。在整个发情周期以及从大鼠交配后的第二天开始直至胚泡着床后的第二天连续几天，测量子宫内膜组织提取物和子宫冲洗液中rDP 200的丰度。结果表明，子宫冲洗液中rDP 200的最高浓度可能与雌激素控制有关，并且可能与着床过程有关。需要进一步的研究来证实这些发现。
