Aoki T, Tsuchida A, Aoki T, Asami K, Uda O, Inoue K, Masuhara S, Kasuya K, Ozawa T, Koyanagi Y
Dept. of Surgery, Tokyo Medical College.
Gan To Kagaku Ryoho. 1998 Jan;25(1):115-8.
We performed the aortic stop flow and hypoxic perfusion chemotherapy for unresectable gallbladder cancer under general anesthesia and made the perfusion only in the abdominal cavity by clamping the abdominal aorta and inferior vena cava near the site of diaphragma. Although temporary hypertension occurred just after clamping the aorta, no severe problem could be seen during operation. After surgery the patient had no abnormalities such as liver or kidney dysfunction, and tumor markers gradually came to decrease. Furthermore, the effectiveness of this therapy is greatly anticipated for the unresectable abdominal cancer, evaluating the selection of anti-cancer drugs and their administration dosage etc.
我们在全身麻醉下对无法切除的胆囊癌实施了主动脉阻断血流和低氧灌注化疗，通过在膈肌附近夹闭腹主动脉和下腔静脉，仅在腹腔内进行灌注。尽管在夹闭主动脉后即刻出现了短暂性高血压，但手术过程中未发现严重问题。术后患者未出现肝肾功能障碍等异常情况，肿瘤标志物逐渐下降。此外，鉴于抗癌药物的选择及其给药剂量等因素，这种治疗方法对无法切除的腹部癌症的有效性被寄予厚望。
