Human and mouse chromosomal mapping of Stac, a neuron-specific protein with an SH3 domain.

Stac is a novel neuron-specific protein consisting of a cysteine-rich domain and an SH3 domain. We determined the chromosomal location of both the mouse and the human Stac genes (Stac and STAC). By linkage analysis using a mouse recombinant inbred (RI) strain panel (BXD), it was determined that Stac is located between D9mit15 and D9mit20 at the distal region of chromosome 9, around which two neurological disease genes, du and tip, have been found. This result was also supported by analysis using an interspecific backcross panel BSS. The mouse chromosomal location around Stac was syntenic with the human chromosome around 3p21-p23, where the gene for cerebellar ataxia (ADCA type II) was recently mapped. By radiation hybrid mapping, STAC was assigned to human chromosome 3p22-p24, and it was found to be distinct from the ADCA type II locus.