人类谷氨酸受体δ2基因（GRID2）定位于4号染色体的4q22区域。
The human glutamate receptor delta 2 gene (GRID2) maps to chromosome 4q22.
作者信息
Hu W, Zuo J, De Jager P L, Heintz N
机构信息
Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021, USA.
出版信息
Genomics. 1998 Jan 1;47(1):143-5. doi: 10.1006/geno.1997.5108.
We isolated the human glutamate receptor delta 2 (GRID2) gene, which has 97.0% identity in amino acid sequence to the mouse glutamate receptor delta 2 (Grid2) gene. We subsequently mapped this gene to human chromosome 4q22 by radiation hybrid mapping and by hybridization to two overlapping human yeast artificial chromosomes that are located in 4q22. The Grid2 gene, which is mutated in lurcher (Lc) mice, maps to mouse chromosome 6. Thus, the mapping of the GRID2 gene to human chromosome 4q22 confirms and refines a region of synteny between mouse and human genomes.
我们分离出了人类谷氨酸受体δ2（GRID2）基因，该基因与小鼠谷氨酸受体δ2（Grid2）基因在氨基酸序列上具有97.0%的同一性。随后，我们通过辐射杂种图谱绘制以及与位于4q22的两个重叠人类酵母人工染色体杂交，将该基因定位到人类4号染色体q22区域。在蹒跚（Lc）小鼠中发生突变的Grid2基因，定位于小鼠6号染色体。因此，GRID2基因在人类4号染色体q22区域的定位证实并细化了小鼠和人类基因组之间的同线性区域。
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