Machida S, Takahashi T, Nomoto K, Murata S
Department of Bacteriology, Saitama Medical School.
Nihon Rinsho. 1998 Jan;56(1):129-33.
Cytomegalovirus(CMV) is ubiquitous in the world, but the rate of CMV antibody positivity (seropositivity) in adults varies geographically. In Japan, CMV seropositivity in adults in 90% and we perceived seronegative adults tend to remain seronegative in 10 years follow up study. We have performed HLA typing 125 seronegative healthy donors of 28 years and up (28-57, Ave.35), and the results were compared with those of healthy donors in same area and whole Japan (data from 10th HLA workshop). Incidence of HLA-A33 and HLA-Cw4 were significantly higher in seronegatives than control groups. This report suggests possible involvement of HLA type in CMV negativity.
巨细胞病毒（CMV）在全球普遍存在，但成人中CMV抗体阳性率（血清阳性）在不同地区有所差异。在日本，成人CMV血清阳性率为90%，并且我们发现在一项为期10年的随访研究中，血清阴性的成年人往往保持血清阴性。我们对125名年龄在28岁及以上（28 - 57岁，平均35岁）的血清阴性健康供者进行了HLA分型，并将结果与同一地区及全日本的健康供者（来自第10届HLA研讨会的数据）进行了比较。血清阴性者中HLA - A33和HLA - Cw4的发生率显著高于对照组。本报告提示HLA类型可能与CMV阴性有关。
