Tanaka-Taya K, Okada S
Department of Pediatrics, Osaka University Medical School.
Nihon Rinsho. 1998 Jan;56(1):208-12.
In our all patients, the antibodies to HHV-6 and -7 were positive before BMT. HHV -6 and -7 DNA were sometimes detected after BMT, and HHV-6 infection after BMT caused fever, interstitial peumonitis, diarrhea, and myelosuppression. However, HHV -7 didn't induce any clinical symptoms. For the diagnosis of the HHV-6 or -7 infection, we used the virus isolation, semiquantitative PCR, and 4-hold elevation of the antibodies to HHV-6 or -7. Ganciclovir, foscarnet, high dose gamma-globulin and high dose acyclovir were useful for the treatment of HHV-6 infection after BMT. HHV-6 is an important agent for the fever of unknown origin, interstitial peumonitis, diarrhea, and myelosuppression after BMT.
在我们所有的患者中，移植前抗人疱疹病毒6型（HHV-6）和抗人疱疹病毒7型（HHV-7）抗体均为阳性。移植后有时可检测到HHV-6和HHV-7 DNA，移植后HHV-6感染可引起发热、间质性肺炎、腹泻和骨髓抑制。然而，HHV-7未诱发任何临床症状。对于HHV-6或HHV-7感染的诊断，我们采用病毒分离、半定量聚合酶链反应（PCR）以及抗HHV-6或抗HHV-7抗体4倍升高的方法。更昔洛韦、膦甲酸钠、大剂量丙种球蛋白和大剂量阿昔洛韦对移植后HHV-6感染的治疗有效。HHV-6是移植后不明原因发热、间质性肺炎、腹泻和骨髓抑制的重要病原体。
