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一种测量未麻醉犬毛细血管出血时间的方法:阿司匹林对出血时间的延长作用。

A method for measuring capillary bleeding time in non-anaesthetized dogs: prolongation of the bleeding time by acetylsalicylic acid.

作者信息

Nolte I, Niemann C, Bowry S K, Failing K, Müller-Berghaus G

机构信息

Hanover School of Veterinary Medicine, Clinic of Small Animals, Germany.

出版信息

Zentralbl Veterinarmed A. 1997 Dec;44(9-10):625-8. doi: 10.1111/j.1439-0442.1997.tb01149.x.

DOI:10.1111/j.1439-0442.1997.tb01149.x
PMID:9465783
Abstract

A reproducible standardized method for measuring capillary bleeding time (CBT) in dogs is presented. The skin was punctured at the toe from a forelimb of non-anaesthetized dogs parallel to the edge of the horny skin of the pad. Before the procedure, a cuff of a sphygmometer was placed above the antibrachium and a hyperaemie agent was applied to the shaved area. The normal CBT in non-anaesthetized dogs was 2.25 +/- 0.76 min (x +/- SD). After injection of acetylsalicylic acid (ASA) (20 mg/kg body weight), CBT was prolonged up to 25 min. Platelet aggregation in response to 10 micrograms collagen/ml was decreased in parallel after treatment with ASA.

摘要

本文介绍了一种可重复的标准化方法,用于测量犬的毛细血管出血时间(CBT)。在未麻醉犬的前肢脚趾处,平行于脚垫角质皮肤边缘穿刺皮肤。在操作前,将血压计袖带置于前臂上方,并将充血剂应用于剃毛区域。未麻醉犬的正常CBT为2.25±0.76分钟(x±SD)。注射乙酰水杨酸(ASA)(20mg/kg体重)后,CBT延长至25分钟。用ASA治疗后,对10微克胶原/毫升的血小板聚集反应平行降低。

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