非节段型白癜风的病情进展：318例患者的临床分析
The progression of nonsegmental vitiligo: clinical analysis of 318 patients.
作者信息
Chun W H, Hann S K
机构信息
Department of Dermatology, Yonsei University College of Medicine, Seoul, South Korea.
出版信息
Int J Dermatol. 1997 Dec;36(12):908-10. doi: 10.1046/j.1365-4362.1997.00320.x.
BACKGROUND
Vitiligo is an acquired disorder with destruction of melanocytes and is characterized by cutaneous depigmentation with a progressive clinical course. We attempted to evaluate whether there was a relationship between the initial site and ultimate progression of nonsegmental vitiligo.
METHODS
Three hundred and eighteen nonsegmental vitiligo patients were examined. Questionnaires regarding age, sex, duration of disease, family history, distribution of initial lesions, progression, and clinical type were recorded from personal interviews and case notes.
RESULTS
Two hundred and eighty nine (90.9%) of the 318 patients showed progression of vitiligo at the time of examination. When the initial sites were the posterior trunk, hands, or feet, there was more progression of vitiligo to other body areas. The progression pattern was usually contiguous to the initial site. When the hands were the initial site, however, vitiligo most commonly progressed to the face.
CONCLUSIONS
There may be a possible relationship between the initial site and ultimate progression of nonsegmental vitiligo. The progression pattern is usually contiguous to the initial site.
背景
白癜风是一种黑素细胞遭到破坏的后天性疾病，其特征为皮肤色素脱失，临床病程呈进行性发展。我们试图评估非节段型白癜风的初始发病部位与最终病情进展之间是否存在关联。
方法
对318例非节段型白癜风患者进行了检查。通过个人访谈和病例记录，记录了有关年龄、性别、病程、家族史、初始皮损分布、病情进展及临床类型的问卷信息。
结果
在318例患者中，有289例（90.9%）在检查时白癜风出现了进展。当初始发病部位为躯干后部、手部或足部时，白癜风向身体其他部位进展的情况更为多见。进展模式通常与初始发病部位相邻。然而，当初始发病部位为手部时，白癜风最常进展至面部。
结论
非节段型白癜风的初始发病部位与最终病情进展之间可能存在关联。进展模式通常与初始发病部位相邻。
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