Hofmeister E K, Kolbert C P, Abdulkarim A S, Magera J M, Hopkins M K, Uhl J R, Ambyaye A, Telford S R, Cockerill F R, Persing D H
Department of Laboratory Medicine and Pathology, Mayo Foundation, Rochester, Minnesota 55905, USA.
J Infect Dis. 1998 Feb;177(2):409-16. doi: 10.1086/514201.
During surveillance for various tickborne pathogens in the upper Midwest during the summer and early fall of 1995, a Bartonella-like agent was detected in the blood of mice that were concurrently infected with Borrelia burgdorferi or Babesia microti (or both). The organism was isolated in pure culture after inoculation of blood from wild-caught mice into C.B-17 scid/scid mice. Phylogenetic analysis of the 16S rRNA and the citrate synthase genes showed that the novel Bartonella species and a Bartonella isolate from a mouse captured on Martha's Vineyard, Massachusetts, were closely related to each other and secondarily related to Bartonella grahamii and Bartonella vinsonii. Further analysis of Peromyscus leucopus blood and tissue samples demonstrated that the novel Bartonella species was exclusively found in conjunction with B. burgdorferi and B. microti. Patent coinfection with these agents may be relatively frequent in naturally infected mice.
在1995年夏末和初秋对中西部上游地区各种蜱传病原体的监测期间，在同时感染伯氏疏螺旋体或微小巴贝斯虫（或两者皆有）的小鼠血液中检测到一种类巴尔通体病原体。将从野外捕获的小鼠采集的血液接种到C.B-17 scid/scid小鼠体内后，该病原体被分离为纯培养物。对16S rRNA和柠檬酸合酶基因的系统发育分析表明，这种新型巴尔通体物种与从马萨诸塞州玛莎葡萄园岛捕获的一只小鼠身上分离出的巴尔通体菌株密切相关，其次与格拉汉姆巴尔通体和文森巴尔通体相关。对白足鼠血液和组织样本的进一步分析表明，这种新型巴尔通体物种仅与伯氏疏螺旋体和微小巴贝斯虫同时存在。在自然感染的小鼠中，这些病原体的显性共感染可能相对常见。
