Martin D R, Walker S J, Baker M G, Lennon D R
Institute of Environmental Science & Research Limited, Communicable Disease Center, Porirua, New Zealand.
J Infect Dis. 1998 Feb;177(2):497-500. doi: 10.1086/517385.
New Zealand is experiencing an epidemic of serogroup B meningococcal disease, which has taken the rate of disease from an average of 1.5/100,000 population in the preepidemic years of 1989 and 1990 to 14.0/100,000 in 1996. Sterile-site isolates of Neisseria meningitidis from cases of invasive disease have been phenotypically characterized by serogrouping, serotyping, and serosubtyping, revealing the involvement of a strain with phenotype B:4:P1.4. Macrorestriction analysis using pulsed-field gel electrophoresis on 667 meningococci isolated from cases during the epidemic has identified the clonal relationship of meningococci expressing the PorA P1.4 antigen. Multilocus enzyme electrophoresis has shown the epidemic strain B:4:P1.4 to belong to lineage III. The recorded characteristics of New Zealand's epidemic are consistent with previous serogroup B epidemics in other parts of the world.
新西兰正在经历B群脑膜炎球菌病的流行，该病发病率已从1989年和1990年流行前的平均每10万人1.5例增至1996年的每10万人14.0例。侵袭性疾病病例的脑膜炎奈瑟菌无菌部位分离株已通过血清群分型、血清型分型和血清亚型分型进行了表型特征分析，结果显示一种表型为B:4:P1.4的菌株参与其中。对流行期间从病例中分离出的667株脑膜炎球菌进行脉冲场凝胶电泳的宏观限制性分析，确定了表达PorA P1.4抗原的脑膜炎球菌的克隆关系。多位点酶电泳显示流行菌株B:4:P1.4属于III型。新西兰此次流行的记录特征与世界其他地区先前的B群流行情况一致。
