Vizcaino A P, Moreno V, Bosch F X, Muñoz N, Barros-Dios X M, Parkin D M
Unit of Field and Intervention Studies, International Agency for Research on Cancer, Lyon, France.
Int J Cancer. 1998 Feb 9;75(4):536-45. doi: 10.1002/(sici)1097-0215(19980209)75:4<536::aid-ijc8>3.0.co;2-u.
Time trends in the incidence of cervical adenocarcinoma and adenosquamous cell carcinomas during the period 1973-1991 were examined using data provided by 60 population-based cancer registries from 32 defined populations in 25 countries. Three components of the incidence trend were studied: age, calendar period of diagnosis and birth cohort. Cumulative incidence rates per 1,000 for 2 groups with age ranges 25-49 and 50-74 years were calculated from the model that best described the incidence data. There was a significant increase in the cumulative incidence of cervical adenocarcinomas in women born in the mid-1930s and in successive cohorts thereafter in some populations in the United States (whites and Hispanic women), Australia, New Zealand (non-Maori), England, Scotland, Denmark, Slovenia, Slovakia and Japan (Osaka) and among Chinese women in Singapore, with a general decline in the incidence in women born in earlier periods. In Sweden and Slovenia there is a suggestion of an increasing trend in both age groups. A decrease in incidence in both age groups was apparent in Finland, France and Italy. There were no changes in incidence in 24 registries covering other European, Asian and black populations in the United States. Part of the increase may be attributable to an increasing prevalence of human papillomavirus infection, and part to improvements in screening.
利用来自25个国家32个特定人群中60个基于人群的癌症登记处提供的数据，对1973年至1991年期间宫颈腺癌和腺鳞癌的发病率随时间的变化趋势进行了研究。对发病率趋势的三个组成部分进行了研究：年龄、诊断的日历时间和出生队列。根据最能描述发病率数据的模型，计算了年龄范围在25至49岁和50至74岁的两组人群每1000人的累积发病率。在美国的一些人群（白人及西班牙裔女性）、澳大利亚、新西兰（非毛利人）、英格兰、苏格兰、丹麦、斯洛文尼亚、斯洛伐克和日本（大阪）以及新加坡的华裔女性中，20世纪30年代中期出生及之后的连续队列中的女性，宫颈腺癌的累积发病率显著上升，而早期出生的女性发病率总体呈下降趋势。在瑞典和斯洛文尼亚，则显示这两个年龄组的发病率都有上升趋势。在芬兰、法国和意大利，两个年龄组的发病率均呈下降趋势。在美国覆盖其他欧洲、亚洲和黑人人群的24个登记处，发病率没有变化。发病率上升的部分原因可能是人类乳头瘤病毒感染率的上升，部分原因是筛查的改善。
