Saetrum Opgaard O, Edvinsson L
Medicinkliniken, Universitetssjukhuset i Lund.
Lakartidningen. 1998 Jan 14;95(3):160-3.
The presence of a network of perivascular nerve fibres has been demonstrated in the adventitia and at the adventitial-medial border of human coronary arteries and veins, and immunocytochemical studies have provided evidence of the co-existence of several neuropeptides in subpopulations of afferent and efferent nerve fibres, supplying the coronary vasculature. The vasoconstrictors neuropeptide Y and noradrenaline see to co-exist in adrenergic perivascular nerve fibres, as distinct from parasympathetic perivascular nerve fibres, and also as distinct from sensory nerves containing immunoreactivity to the vasodilators substance P and calcitonin gene-related peptide. On the other hand, immunoreactivity to the vasoconstrictor, endothelin, has been demonstrated throughout the endothelial cell layer of human coronary arteries and veins. Although the physiological function of these substances is still uncertain, both their rich supply in and around coronary arteries and veins and their capacity to induce significant changes in vascular tone suggest them to be involved in the regulation of coronary blood flow.
在人类冠状动脉和静脉的外膜以及外膜与中膜的边界处，已证实存在血管周围神经纤维网络，免疫细胞化学研究提供了证据，表明在供应冠状血管系统的传入和传出神经纤维亚群中，几种神经肽共存。血管收缩剂神经肽Y和去甲肾上腺素似乎共存于肾上腺素能血管周围神经纤维中，这与副交感神经血管周围神经纤维不同，也与对血管扩张剂P物质和降钙素基因相关肽有免疫反应性的感觉神经不同。另一方面，在人类冠状动脉和静脉的整个内皮细胞层中已证实存在对血管收缩剂内皮素的免疫反应性。尽管这些物质的生理功能仍不确定，但它们在冠状动脉和静脉及其周围的丰富供应以及它们诱导血管张力显著变化的能力表明它们参与了冠状动脉血流的调节。
