Lodi G, Porter S R
Department of Oral Medicine, Eastman Dental Institute for Oral Health Care Sciences, University of London, UK.
Oral Dis. 1997 Jun;3(2):77-81. doi: 10.1111/j.1601-0825.1997.tb00016.x.
To review the current literature regarding the association of lichen planus (LP) and liver disease, with particular attention to the association of the oral variant of the disease with hepatitis C virus (HCV) infection.
Available literature of the possible association of LP with systemic disorders, in particular chronic hepatic disease, has been reviewed.
LP is sometimes associated with infectious or autoimmune disease and/or neoplasia, however an aetiological association between LP and these disorders seems unlikely. A more consistent association exists between LP and chronic hepatic disease. The precise cause of this association is not known. However, in the last 6 years a notable association between HCV infection and LP has been observed, particularly in patients in Spain, Italy and Japan. The pathogenesis of this possible HCV-associated LP is not known, but it may involve a cell mediated response to an altered epithelial antigen.
There is now evidence to suggest a significant association between HCV infection and LP in some groups of patients.
回顾当前关于扁平苔藓（LP）与肝脏疾病关联的文献，尤其关注该疾病口腔型与丙型肝炎病毒（HCV）感染的关联。
对LP与全身性疾病，特别是慢性肝病可能关联的现有文献进行了综述。
LP有时与感染性或自身免疫性疾病和/或肿瘤形成有关，然而LP与这些疾病之间的病因学关联似乎不太可能。LP与慢性肝病之间存在更一致的关联。这种关联的确切原因尚不清楚。然而，在过去6年中，已观察到HCV感染与LP之间存在显著关联，特别是在西班牙、意大利和日本的患者中。这种可能与HCV相关的LP的发病机制尚不清楚，但可能涉及对改变的上皮抗原的细胞介导反应。
现在有证据表明，在某些患者群体中，HCV感染与LP之间存在显著关联。
