Contreras A, Slots J
Department of Periodontology, School of Dentistry, University of Southern California, Los Angeles 90089-0641, USA.
Oral Microbiol Immunol. 1996 Dec;11(6):381-6. doi: 10.1111/j.1399-302x.1996.tb00199.x.
A prior investigation has demonstrated a higher prevalence of human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) in subgingival specimens from periodontitis patients than from gingivitis patients. This study aimed to determine the frequency of HCMV, EBV-1, EBV-2, herpes simplex virus (HSV) and human immunodeficiency virus (HIV) in subgingival samples from 27 adults who each contributed both a periodontitis and a gingivitis site. Viral detection was performed using a nested-polymerase chain reaction method. Twenty-four subjects (89%) yielded at least one of the five test viruses from deep periodontal pockets, whereas only 15 (56%) showed viruses from shallow periodontal sites (P = 0.015; chi-square test). Viral co-infection occurred more frequently in deep than in shallow periodontal sites (P = 0.015). HCMV was detected with higher frequency in deep than in shallow periodontal sites (P = 0.023). The possible periodontopathogenic mechanisms of mammalian viruses in human periodontitis are discussed. The role and importance of HCMV and other mammalian viruses in the initiation and progression of destructive periodontal disease merits further investigation.
先前的一项调查表明，与牙龈炎患者相比，牙周炎患者龈下样本中人类巨细胞病毒（HCMV）和爱泼斯坦-巴尔病毒（EBV）的患病率更高。本研究旨在确定27名成年人龈下样本中HCMV、EBV-1、EBV-2、单纯疱疹病毒（HSV）和人类免疫缺陷病毒（HIV）的感染频率，这些成年人每人都提供了一个牙周炎部位和一个牙龈炎部位的样本。使用巢式聚合酶链反应方法进行病毒检测。24名受试者（89%）在深部牙周袋中检测出至少一种测试病毒，而只有15名（56%）在浅部牙周部位检测出病毒（P = 0.015；卡方检验）。病毒合并感染在深部牙周部位比在浅部牙周部位更常见（P = 0.015）。在深部牙周部位检测到HCMV的频率高于浅部牙周部位（P = 0.023）。本文讨论了哺乳动物病毒在人类牙周炎中可能的牙周致病机制。HCMV和其他哺乳动物病毒在破坏性牙周疾病的发生和发展中的作用及重要性值得进一步研究。
