Benda R K, Porter A T
Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI 48202, USA.
Crit Rev Oncog. 1996;7(5-6):457-64. doi: 10.1615/critrevoncog.v7.i5-6.40.
Invasive bladder cancer remains a therapeutic challenge. Approximately 50% of patients treated with radical cystectomy die of metastatic disease. External beam radiation therapy when given alone has results inferior to that of surgery, and although it has shown some benefit when given in the preoperative setting, this was not verified by randomized trials. Altered fractionation radiation schemes and combined modality using a cisplatin-based combination chemotherapy with radiation have resulted in up to 60% bladder preservation.
浸润性膀胱癌仍然是一个治疗难题。接受根治性膀胱切除术的患者中约有50%死于转移性疾病。单独进行外照射放疗的效果不如手术，尽管术前放疗已显示出一定益处，但随机试验并未证实这一点。改变分割放疗方案以及采用基于顺铂的联合化疗与放疗的综合治疗方式，已使膀胱保留率高达60%。
