Kainer F, Prechtl H F, Engele H, Einspieler C
Department of Obstetrics and Gynaecology, München University, Germany.
Early Hum Dev. 1997 Nov 24;50(1):13-25. doi: 10.1016/s0378-3782(97)00089-3.
The effect of type-I diabetes on the quality of general movements (GMs) was studied longitudinally in 12 human fetuses. GMs were analysed at two-weekly intervals from 16 weeks until delivery. A pregnancy optimality-score and a diabetes optimality-score were used to cover the course of the pregnancy and delivery and the severity of diabetes. GMs of infants were analysed 1, 4-6, and 12-18 weeks after birth and the Bayley developmental test was performed at 10 months. All fetuses showed normal GMs at 16 weeks. From 20 weeks onwards until delivery five fetuses developed abnormal GMs. The diabetes optimality-score was significantly lower in the group with abnormal GMs (P = 0.018) whereas the pregnancy optimality-score did not differ between fetuses with normal and abnormal GMs. Our results indicate that type-I diabetes can have a negative impact on prenatally observed GMs. Consistently normal GMs indicate normal neurodevelopmental outcome at 10 months whereas in the group with abnormal GMs reduced Bayley-scores may occur.
对12例人类胎儿进行了纵向研究，以探讨I型糖尿病对全身运动（GMs）质量的影响。从孕16周直到分娩，每隔两周对GMs进行分析。采用妊娠优化评分和糖尿病优化评分来涵盖妊娠和分娩过程以及糖尿病的严重程度。在出生后1周、4 - 6周以及12 - 18周对婴儿的GMs进行分析，并在10个月时进行贝利发育测试。所有胎儿在16周时GMs均正常。从20周起直至分娩，有5例胎儿出现了异常GMs。GMs异常组的糖尿病优化评分显著更低（P = 0.018），而GMs正常和异常的胎儿之间妊娠优化评分并无差异。我们的结果表明，I型糖尿病可能对产前观察到的GMs产生负面影响。持续正常的GMs表明10个月时神经发育结果正常，而在GMs异常组中可能出现贝利评分降低的情况。
