Gavaghan B J, Kittleson M D
Veterinary Medical Teaching Hospital, University of California, Davis 95616, USA.
Aust Vet J. 1997 Dec;75(12):862-8. doi: 10.1111/j.1751-0813.1997.tb11253.x.
An American Cocker Spaniel with low plasma taurine concentration (< 2 nmol/mL) was presented with dyspnoea associated with pulmonary oedema and a left ventricular shortening fraction of 9%. Emergency therapy with furosemide, dobutamine, nitroglycerine and oxygen supplementation led to a good response. Chronic therapy was started with enalapril, furosemide, digoxin and taurine. Improvement in all echocardiographic indices were noted over a 22 week follow-up, most notably an increase in left ventricular shortening fraction to 20%, a decrease of E-point septal separation from 14 mm to 7 mm and marked left ventricular remodelling. This degree of improvement in myocardial function may represent a direct link between dilated cardiomyopathy in the American Cocker Spaniel and plasma taurine deficiency. Alternatively, this response may reflect a breed-related cardiomyopathy with a natural history and therapeutic response not commonly seen in the more common large breed cardiomyopathy presentations.
一只血浆牛磺酸浓度较低（<2 nmol/mL）的美国可卡犬出现呼吸困难，伴有肺水肿，左心室缩短分数为9%。使用呋塞米、多巴酚丁胺、硝酸甘油和补充氧气进行紧急治疗后反应良好。开始使用依那普利、呋塞米、地高辛和牛磺酸进行长期治疗。在22周的随访中，所有超声心动图指标均有改善，最显著的是左心室缩短分数增加到20%，E点至室间隔距离从14毫米降至7毫米，以及明显的左心室重塑。心肌功能的这种改善程度可能代表了美国可卡犬扩张型心肌病与血浆牛磺酸缺乏之间的直接联系。或者，这种反应可能反映了一种与品种相关的心肌病，其自然病史和治疗反应在更常见的大型犬种心肌病表现中并不常见。
