Cardiology Service, Small Animal Teaching Hospital, Institute of Infection, Veterinary and Ecological Science, University of Liverpool, Neston, Chester, CH64 7TE, UK.
Cardiology Service, Willows Veterinary Centre and Referral Service, Shirley, Solihull, B90 4NH, UK.
J Small Anim Pract. 2021 Jul;62(7):570-579. doi: 10.1111/jsap.13306. Epub 2021 Feb 16.
The aims of this study were to evaluate taurine levels in English cocker spaniels with dilated cardiomyopathy and assess their survival time and natural progression of their disease.
Retrospective comparison of English cocker spaniels with dilated cardiomyopathy phenotype with and without taurine deficiency at the cardiology department of a UK academic referral centre between 2008 and 2018.
Taurine plasma concentration was available in 16 English cocker spaniels with dilated cardiomyopathy phenotype; 13 of 16 had congestive heart failure and three of 16 did not. Taurine concentration was low (<50 μmol/L) in 13 of 16 and normal in three of 16. Deficient dogs received taurine supplementation in addition to conventional cardiac medications. Eight dogs were still alive at the end of this study and eight were dead. MST for all dogs included in the study was 2800 days. Left ventricular systolic function improved and left ventricular dimensions reduced in English cocker spaniels with taurine deficiency following taurine supplementation and conventional cardiac therapy, although similar results were observed in English cocker spaniels with normal taurine concentration on cardiac therapy alone.
Based on laboratory reference intervals, low taurine concentrations were common in English cocker spaniels with dilated cardiomyopathy, showing a possible association between dilated cardiomyopathy in English cocker spaniels and taurine deficiency; supplementation with taurine was not curative.
本研究旨在评估英国可卡犬扩张型心肌病中的牛磺酸水平，并评估其存活时间和疾病的自然进程。
2008 年至 2018 年，在英国一家学术转诊中心的心脏病科，对具有扩张型心肌病表型的英国可卡犬进行回顾性比较，比较有无牛磺酸缺乏症的犬。
共有 16 只具有扩张型心肌病表型的英国可卡犬的牛磺酸血浆浓度可用；其中 13 只患有充血性心力衰竭，3 只未患有充血性心力衰竭。16 只犬中有 13 只牛磺酸浓度较低（<50μmol/L），3 只犬牛磺酸浓度正常。缺乏牛磺酸的犬在接受常规心脏药物治疗的同时，还接受了牛磺酸补充剂治疗。本研究结束时，8 只犬仍存活，8 只犬死亡。所有纳入研究的犬的 MST 为 2800 天。在接受牛磺酸补充剂和常规心脏治疗后，牛磺酸缺乏的英国可卡犬的左心室收缩功能得到改善，左心室尺寸减小，尽管在单独接受心脏治疗的牛磺酸浓度正常的英国可卡犬中也观察到了类似的结果。
根据实验室参考区间，患有扩张型心肌病的英国可卡犬的牛磺酸浓度较低，这表明扩张型心肌病与牛磺酸缺乏之间可能存在关联；牛磺酸补充剂不是治疗方法。
