Adair C D, Gunter M, Stovall T G, McElroy G, Veille J C, Ernest J M
Department of Obstetrics and Gynecology, The Bowman Gray School of Medicine/Wake Forest University, Winston-Salem, North Carolina, USA.
Obstet Gynecol. 1998 Feb;91(2):165-8. doi: 10.1016/s0029-7844(97)00586-3.
To determine side effect profiles and cure rates of azithromycin compared with erythromycin in the treatment of chlamydial cervicitis complicating pregnancy.
Pregnant patients with positive DNA antigen assays for Chlamydia trachomatis were randomized to either azithromycin, 1 g oral slurry in a single dose, or erythromycin, 500 mg every 6 hours for 7 days. Repeat assays were planned for 3 weeks after therapy. Side effects, compliance, and treatment efficacy were assessed.
One hundred six women were enrolled, and eighty-five women completed the protocol. Significantly fewer gastrointestinal side effects were noted in the azithromycin group than in the erythromycin group (11.9% versus 58.1%, P < or = .01). Enhanced compliance was noted with azithromycin, because it was given in a single observed dose. Similar treatment efficacy was noted between azithromycin and erythromycin (88.1% versus 93.0%, P > .05).
Compared with erythromycin, azithromycin is associated with significantly fewer gastrointestinal side effects in pregnancy. This association, along with the ease of administration and similar efficacy, suggests that azithromycin should be considered for the initial treatment of chlamydial cervicitis in pregnancy.
确定阿奇霉素与红霉素相比，在治疗合并妊娠的衣原体宫颈炎时的副作用情况和治愈率。
沙眼衣原体DNA抗原检测呈阳性的孕妇被随机分为两组，一组服用单剂量1克口服混悬剂的阿奇霉素，另一组每6小时服用500毫克红霉素，共7天。计划在治疗后3周进行重复检测。评估副作用、依从性和治疗效果。
106名女性入组，85名女性完成方案。阿奇霉素组胃肠道副作用明显少于红霉素组（11.9%对58.1%，P≤0.01）。阿奇霉素的依从性更好，因为它是单剂量给药且有观察。阿奇霉素和红霉素的治疗效果相似（88.1%对93.0%，P＞0.05）。
与红霉素相比，阿奇霉素在妊娠时胃肠道副作用明显较少。这种关联，连同给药方便和疗效相似，表明阿奇霉素应被考虑用于妊娠衣原体宫颈炎的初始治疗。
