Bush M R, Rosa C
Department of Obstetrics and Gynecology, William Beaumont Army Medical Center, El Paso, Texas.
Obstet Gynecol. 1994 Jul;84(1):61-3.
To compare azithromycin and erythromycin in regard to side effects, intolerance, and cure rate in a pregnant population with chlamydial cervicitis.
Thirty women were randomized to receive either erythromycin, 500 mg orally four times a day for 7 days, or azithromycin, 1 g orally as one dose. All subjects completed questionnaires identifying the incidence of nausea, vomiting, diarrhea, abdominal pain, and anorexia. Post-treatment cultures were taken from all subjects.
All subjects receiving erythromycin reported two or more gastrointestinal side effects, versus none in the azithromycin group (P < .001). Five of 15 subjects in the erythromycin treatment arm were intolerant to the 500-mg dose given four times a day, compared to none in the azithromycin group (P < .025), so the dosage was lowered to 250 mg four times a day to complete the course. Repeat cervical testing demonstrated similar cure rates for both medications: 100 and 93% (14 of 15) for azithromycin and erythromycin, respectively.
These data suggest that azithromycin is a valid treatment option in pregnant patients who cannot tolerate erythromycin because of side effects.
比较阿奇霉素和红霉素在衣原体宫颈炎孕妇人群中的副作用、不耐受情况及治愈率。
30名女性被随机分为两组，一组接受红霉素治疗，口服500毫克，每日4次，共7天；另一组接受阿奇霉素治疗，口服1克，单次给药。所有受试者均填写问卷，记录恶心、呕吐、腹泻、腹痛和厌食的发生率。治疗后对所有受试者进行培养。
所有接受红霉素治疗的受试者均报告有两种或更多胃肠道副作用，而阿奇霉素组无一例出现（P <.001）。红霉素治疗组15名受试者中有5名对每日4次给予的500毫克剂量不耐受，阿奇霉素组则无（P <.025），因此将红霉素剂量降至每日4次，每次250毫克以完成疗程。重复宫颈检测显示两种药物的治愈率相似：阿奇霉素和红霉素的治愈率分别为100%和93%（15例中的14例）。
这些数据表明，对于因副作用而无法耐受红霉素的孕妇患者，阿奇霉素是一种有效的治疗选择。
