Eltabbakh G H, Piver M S, Natarajan N, Mettlin C J
Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.
Obstet Gynecol. 1998 Feb;91(2):254-9. doi: 10.1016/s0029-7844(97)00650-9.
To describe the epidemiologic features of women with extraovarian primary peritoneal carcinoma and compare them with those of women with primary epithelial ovarian cancer.
The epidemiologic features of 50 women with extraovarian primary peritoneal carcinoma were compared with those of 503 women with primary epithelial ovarian cancer. We included all women with the respective diagnoses admitted to the Roswell Park Cancer Institute between October 1982 and October 1996 who returned an epidemiologic questionnaire. Epidemiologic features of the study and control groups were extracted from a database compiled from a self-administered questionnaire that has been given to patients as part of the admission process since 1982. Individual variables between the study and control groups were compared using Student t test, chi2 analysis, and Wilcoxon nonparametric test. Two-tailed P < .05 was considered significant.
We found few significantly different epidemiologic features between women with extraovarian primary peritoneal carcinoma and those with primary epithelial ovarian cancer. Women with extraovarian primary peritoneal carcinoma were significantly older (mean age 63.8 versus 55.0 years, P < .001), had later menarche (13.3 versus 12.8 years, P = .024), and were less likely to have used perineal talc powder (26.0% versus 48.1%, P = .003). There were no significant differences with respect to reproductive history, contraceptive use, or use of hormone replacement therapy. A larger proportion of ovarian cancer patients reported a family history of breast cancer, but the numbers were too small to reach statistical significance.
The epidemiologic features of women with extraovarian primary peritoneal carcinoma compared with women with primary epithelial ovarian cancer show few differences. The observed areas of difference warrant further research to determine whether they suggest the occurrence of distinct disease entities.
描述原发性卵巢外腹膜癌女性的流行病学特征，并将其与原发性上皮性卵巢癌女性的流行病学特征进行比较。
将50例原发性卵巢外腹膜癌女性的流行病学特征与503例原发性上皮性卵巢癌女性的流行病学特征进行比较。我们纳入了1982年10月至1996年10月期间入住罗斯韦尔公园癌症研究所且返回流行病学调查问卷的所有确诊为相应疾病的女性。研究组和对照组的流行病学特征是从一个数据库中提取的，该数据库由一份自填式问卷汇编而成，自1982年起作为入院流程的一部分发放给患者。使用学生t检验、卡方分析和威尔科克森非参数检验比较研究组和对照组之间的个体变量。双侧P < 0.05被认为具有统计学意义。
我们发现原发性卵巢外腹膜癌女性与原发性上皮性卵巢癌女性之间在流行病学特征上几乎没有显著差异。原发性卵巢外腹膜癌女性年龄显著更大（平均年龄63.8岁对55.0岁，P < 0.001），初潮年龄更晚（13.3岁对12.8岁，P = 0.024），使用会阴滑石粉的可能性更小（26.0%对48.1%，P = 0.003）。在生殖史、避孕措施使用或激素替代疗法使用方面没有显著差异。较大比例的卵巢癌患者报告有乳腺癌家族史，但人数太少，未达到统计学意义。
原发性卵巢外腹膜癌女性与原发性上皮性卵巢癌女性的流行病学特征差异不大。观察到的差异领域值得进一步研究，以确定它们是否表明存在不同的疾病实体。
