Piver M S, Jishi M F, Tsukada Y, Nava G
Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, New York 14263.
Cancer. 1993 May 1;71(9):2751-5. doi: 10.1002/1097-0142(19930501)71:9<2751::aid-cncr2820710911>3.0.co;2-j.
According to previous reports, primary peritoneal carcinoma indistinguishable from primary ovarian adenocarcinoma had developed in five women with a history of familial ovarian cancer who had undergone prophylactic oophorectomy.
The records from the Gilda Radner Familial Ovarian Cancer Registry were reviewed for instances of prophylactic oophorectomy and cases of primary peritoneal carcinoma occurring after prophylactic oophorectomy.
From 1981 through July 1992, the Gilda Radner Familial Ovarian Cancer Registry accessioned 931 families (a total of 2221 cases of familial ovarian cancer). Currently, 324 women in these families have undergone prophylactic oophorectomy as a preventive measure against the subsequent development of ovarian cancer. Primary peritoneal carcinoma indistinguishable histologically from primary ovarian adenocarcinoma has developed in six of these women 1-27 years after prophylactic oophorectomy.
Based on this finding and other reports of such primary peritoneal carcinoma, a prospective international study is planned. This study will compare the incidence of peritoneal carcinoma in first- or second-degree relatives who underwent prophylactic oophorectomy because of a family history of ovarian cancer with that of those who did not undergo prophylactic oophorectomy.
根据既往报道，5名有家族性卵巢癌病史且已接受预防性卵巢切除术的女性发生了与原发性卵巢腺癌难以鉴别的原发性腹膜癌。
查阅吉尔达·拉德纳家族性卵巢癌登记处的记录，以了解预防性卵巢切除术的病例以及预防性卵巢切除术后发生原发性腹膜癌的病例。
从1981年至1992年7月，吉尔达·拉德纳家族性卵巢癌登记处收纳了931个家族（共2221例家族性卵巢癌病例）。目前，这些家族中有324名女性已接受预防性卵巢切除术作为预防卵巢癌后续发生的措施。其中6名女性在预防性卵巢切除术后1至27年发生了组织学上与原发性卵巢腺癌难以鉴别的原发性腹膜癌。
基于这一发现以及其他有关此类原发性腹膜癌的报道，计划开展一项前瞻性国际研究。该研究将比较因卵巢癌家族史而接受预防性卵巢切除术的一级或二级亲属与未接受预防性卵巢切除术的亲属中腹膜癌的发病率。
