Aeschbach D, Matthews J R, Postolache T T, Jackson M A, Giesen H A, Wehr T A
Clinical Psychobiology Branch, National Institute of Mental Health, Bethesda, MD 20892, USA.
Neurosci Lett. 1997 Dec 19;239(2-3):121-4. doi: 10.1016/s0304-3940(97)00904-x.
The electroencephalogram (EEG) of nine healthy individuals was recorded at half-hourly intervals during approximately 40 h of sustained wakefulness in a constant routine protocol. EEG power density in the 0.75-9.0 Hz range exhibited a global increasing trend, and a local trough in the evening, centered approximately 6 h prior to the temperature minimum. The former could be attributed to a wake-dependent influence, and the latter to a circadian influence. Power density in the 9.25-12.0 Hz band showed a circadian modulation, the trough coinciding with the minimum of the endogenous rhythm of body temperature, whereas a wake-dependent influence was not evident. Power density in the 12.25-25.0 Hz range exhibited a wake-dependent increase, whereas a circadian modulation was absent. It is concluded that the circadian pacemaker and the wake-dependent (i.e. homeostatic) process affect the waking EEG in a frequency-specific manner.
在一个固定程序方案中，对9名健康个体在持续清醒约40小时期间每隔半小时记录一次脑电图（EEG）。在0.75 - 9.0赫兹范围内的EEG功率密度呈现出整体上升趋势，且在傍晚出现一个局部低谷，该低谷大致出现在体温最低前约6小时。前者可归因于与清醒相关的影响，后者可归因于昼夜节律的影响。在9.25 - 12.0赫兹频段的功率密度呈现出昼夜节律调制，低谷与体温内源性节律的最小值重合，而与清醒相关的影响不明显。在12.25 - 25.0赫兹范围内的功率密度呈现出与清醒相关的增加，而不存在昼夜节律调制。结论是，昼夜节律起搏器和与清醒相关（即稳态）的过程以频率特异性方式影响清醒时的脑电图。
