Graham S J, Bronskill M J, Henkelman R M
Sunnybrook Health Science Centre and Department of Medical Biophysics, University of Toronto, Ontario, Canada.
Magn Reson Med. 1998 Feb;39(2):198-203. doi: 10.1002/mrm.1910390206.
Detailed measurements of the T1-weighted, T2-weighted, and MT-weighted signal were performed for ex vivo muscle samples heated to various temperatures for different times. Consistent, monotonic increases in signal intensity were observed with progressive thermal coagulation, corresponding to an increase in T2 relaxation time and an increase in MT-weighted signal for temperatures above 60 degrees C. The relationship for T1 relaxation was more complex, showing a decrease in T1 relaxation from 40 to 60 degrees C and an increase above 60 degrees C. These techniques provide a more direct measure of tissue thermal coagulation than that provided by MR thermometry and suggest MR imaging strategies for the optimization and monitoring of thermal coagulation therapy protocols that create thermal damage in target tissues.
对在不同时间加热到不同温度的离体肌肉样本进行了T1加权、T2加权和MT加权信号的详细测量。随着热凝固的进展，观察到信号强度持续、单调增加，这对应于T2弛豫时间的增加以及温度高于60摄氏度时MT加权信号的增加。T1弛豫的关系更为复杂，在40至60摄氏度时T1弛豫时间减少，高于60摄氏度时增加。与磁共振测温法相比，这些技术能更直接地测量组织热凝固，并为优化和监测在靶组织中造成热损伤的热凝固治疗方案提供了磁共振成像策略。
