Mohri H, Bonhoeffer S, Monard S, Perelson A S, Ho D D
Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Avenue, New York, NY 10016, USA.
Science. 1998 Feb 20;279(5354):1223-7. doi: 10.1126/science.279.5354.1223.
Studies of lymphocyte turnover in animal models have implications for understanding the mechanism of cell killing and the extent of lymphocyte regeneration in human immunodeficiency virus infection. Quantitative analyses of the sequential changes in bromodeoxyuridine labeling of CD4 and CD8 T lymphocytes not only revealed the normal proliferation and death rates of these cell populations in uninfected macaques, but also showed a substantial increase in these rates associated with simian immunodeficiency virus (SIV) infection. Faster labeling and delabeling in memory and naïve T lymphocyte subpopulations as well as in NK (natural killer) and B cells were also observed in infected macaques, suggesting a state of generalized activation induced by SIV.
动物模型中淋巴细胞更新的研究对于理解人类免疫缺陷病毒感染时细胞杀伤机制及淋巴细胞再生程度具有重要意义。对CD4和CD8 T淋巴细胞溴脱氧尿苷标记的连续变化进行定量分析，不仅揭示了未感染猕猴中这些细胞群体的正常增殖和死亡率，还显示出与猴免疫缺陷病毒（SIV）感染相关的这些比率大幅增加。在感染的猕猴中还观察到记忆性和初始T淋巴细胞亚群以及NK（自然杀伤）细胞和B细胞中标记和去标记速度更快，这表明SIV诱导了全身激活状态。
