目前对人类T细胞动力学的估计。
Current estimates of T cell kinetics in humans.
作者信息
Macallan Derek C, Busch Robert, Asquith Becca
机构信息
Institute for Infection and Immunity, St George's, University of London, London, UK.
Department of Life Sciences, University of Roehampton, London, UK.
出版信息
Curr Opin Syst Biol. 2019 Dec;18:77-86. doi: 10.1016/j.coisb.2019.10.002.
Stable isotope labeling is a generally applicable method of quantifying cell dynamics. Its advent has opened up the way for the quantitative study of T cells in humans. However, the literature is confusing as estimates vary by orders of magnitude between studies. In this short review we aim to explain the reasons for the discrepancies in estimates, clarify which estimates have been superseded and why and highlight the current best estimates. We focus on stable isotope labeling of T cell subsets in healthy humans.
稳定同位素标记是一种普遍适用的量化细胞动态的方法。它的出现为人类T细胞的定量研究开辟了道路。然而，文献令人困惑，因为不同研究之间的估计相差几个数量级。在这篇简短的综述中，我们旨在解释估计差异的原因，阐明哪些估计已被取代以及原因，并突出当前的最佳估计。我们专注于健康人类T细胞亚群的稳定同位素标记。
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