David J M, Barthelemy I, Bonnet F, Mihura J, Daly-Schveitzer N
Centre Claudius Regaud, Toulouse.
Rev Stomatol Chir Maxillofac. 1997 Dec;98(5):306-11.
Squamous cell carcinomas of the oral cavity were treated in 157 patients by surgery as first-line (104) or salvage (53) treatment. Postoperative irradiation delivered either for locally advanced tumors (stade III-IV) or for unfavorable histological data (nodal or surgical margins involvement). The retrospective study with a mean time of follow-up of 2.5 years shows a loco-regional control rate of 75% statistically influenced by histological nodal status (p < 0.01). Cumulative and cause specific survival rates at 5 years are 41.1% and 57.2% respectively. T stage was found to be a prognostic factor of survival (p < 0.01) as bone involvement (p < 0.05). Surgical margins are influent on local control and survival only in absence of radiation.
157例口腔鳞状细胞癌患者接受了手术治疗，作为一线治疗（104例）或挽救性治疗（53例）。术后放疗用于局部晚期肿瘤（Ⅲ-Ⅳ期）或组织学数据不佳（淋巴结或手术切缘受累）的情况。这项平均随访时间为2.5年的回顾性研究显示，局部区域控制率为75%，受组织学淋巴结状态的统计学影响（p<0.01）。5年时的累积生存率和特定病因生存率分别为41.1%和57.2%。发现T分期是生存的预后因素（p<0.01），骨受累也是（p<0.05）。手术切缘仅在未进行放疗的情况下对局部控制和生存有影响。
