肾上腺雄激素与青春期前品行障碍男孩及正常对照儿童的攻击性
Adrenal androgens and aggression in conduct disorder prepubertal boys and normal controls.
作者信息
van Goozen S H, Matthys W, Cohen-Kettenis P T, Thijssen J H, van Engeland H
机构信息
Department of Child and Adolescent Psychiatry, University Hospital Utrecht, The Netherlands.
出版信息
Biol Psychiatry. 1998 Jan 15;43(2):156-8. doi: 10.1016/S0006-3223(98)00360-6.
BACKGROUND
The evidence for a role of androgens in human aggression is less convincing than in animals. We examined the relationship between androgens and aggression in prepubertal boys who were diagnosed as suffering from severe aggression and antisocial behavior.
METHODS
Plasma levels of testosterone (T), androstenedione (A), and dehydroepiandrosterone sulphate (DHEAS) were measured in 15 boys with a conduct disorder (CD) and 25 normal control (NC) boys. Parents and teachers of the children rated the intensity of aggression and delinquency over the last 6 months.
RESULTS
CD boys had significantly higher levels of DHEAS and marginally significantly higher levels of A; there were no differences in T. Moreover, DHEAS levels were significantly positively correlated with the intensity of aggression and delinquency as rated by both parents and teachers.
CONCLUSIONS
The results suggest that adrenal androgen functioning plays an important role in the onset and maintenance, of aggression in young boys.
背景
雄激素在人类攻击行为中所起作用的证据，不如在动物中那样有说服力。我们研究了被诊断患有严重攻击行为和反社会行为的青春期前男孩体内雄激素与攻击行为之间的关系。
方法
测定了15名患有品行障碍（CD）的男孩和25名正常对照（NC）男孩的血浆睾酮（T）、雄烯二酮（A）和硫酸脱氢表雄酮（DHEAS）水平。孩子们的父母和老师对其在过去6个月里攻击行为和违法犯罪行为的强度进行了评分。
结果
患有品行障碍的男孩DHEAS水平显著更高，A水平略高但差异显著；T水平无差异。此外，DHEAS水平与父母和老师评定的攻击行为和违法犯罪行为强度均呈显著正相关。
结论
结果表明，肾上腺雄激素功能在年幼男孩攻击行为的发生和维持中起重要作用。
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