van Goozen S H, van den Ban E, Matthys W, Cohen-Kettenis P T, Thijssen J H, van Engeland H
Department of Child and Adolescent Psychiatry, Utrecht University Medical Centre, The Netherlands.
J Am Acad Child Adolesc Psychiatry. 2000 Nov;39(11):1446-51. doi: 10.1097/00004583-200011000-00020.
To examine the relationship between adrenal androgens and aggression in children with oppositional and antisocial behavior and to compare their levels with those of psychiatric and normal controls.
Dehydroepiandrosterone sulfate (DHEAS) was measured in 24 children with oppositional defiant disorder (ODD), 42 psychiatric controls (including 20 children with attention-deficit/hyperactivity disorder [ADHD]), and 30 normal controls. The children's parents filled out the Child Behavior Checklist (CBCL).
Children with ODD had higher DHEAS levels than either the psychiatric control or normal control groups; DHEAS levels of the latter groups did not differ. Moreover, it was possible to classify children as having either ODD or ADHD on the basis of their DHEAS levels, whereas this was not the case on the basis of the CBCL data.
The results indicate that adrenal androgen functioning is specifically elevated in children with ODD. It is speculated that the mechanism could be a shift in balance of ACTH-beta-endorphin functioning in the hypothalamic-pituitary-adrenal axis due to early stress or genetic factors.
研究患有对立违抗和反社会行为的儿童中肾上腺雄激素与攻击行为之间的关系，并将他们的水平与精神疾病对照组和正常对照组进行比较。
对24名对立违抗障碍（ODD）儿童、42名精神疾病对照组儿童（包括20名注意力缺陷多动障碍[ADHD]儿童）和30名正常对照组儿童测量硫酸脱氢表雄酮（DHEAS）。儿童的父母填写儿童行为量表（CBCL）。
ODD儿童的DHEAS水平高于精神疾病对照组或正常对照组；后两组的DHEAS水平没有差异。此外，根据DHEAS水平可以将儿童分类为患有ODD或ADHD，而根据CBCL数据则无法做到。
结果表明，ODD儿童的肾上腺雄激素功能特别增强。据推测，其机制可能是由于早期压力或遗传因素导致下丘脑-垂体-肾上腺轴中促肾上腺皮质激素-β-内啡肽功能平衡发生改变。
