Nishikawa M, Shouzu A, Imai Y, Yonemoto T, Shimizu H, Miyake Y, Hayakawa T, Omoto S, Nomura S, Inada M
Second Department of Internal Medicine, Kansai Medical University, Moriguchi, Osaka.
Intern Med. 1997 Dec;36(12):935-7. doi: 10.2169/internalmedicine.36.935.
A 30-year-old Japanese female developed insulin-dependent diabetes mellitus (IDDM). She later complained of muscle pains at the age of 37. Erythrocyte sedimentation rate and C-reactive protein were abnormal, with negative antinuclear antibody and rheumatoid factor tests. The diagnosis of polymyalgia rheumatica (PMR) was made. She had HLA phenotypes including A2 and without DR4, consistent with common types of Japanese PMR. Her DNA typing included DQB1*0303 which is positively associated with Japanese IDDM. It seems likely that she suffered from these diseases at a young age on the basis of having the HLA-susceptibility to both PMR and IDDM.
一名30岁的日本女性患了胰岛素依赖型糖尿病（IDDM）。她后来在37岁时诉说肌肉疼痛。红细胞沉降率和C反应蛋白异常，抗核抗体和类风湿因子检测为阴性。诊断为风湿性多肌痛（PMR）。她的HLA表型包括A2且无DR4，与日本常见的PMR类型一致。她的DNA分型包括与日本IDDM呈正相关的DQB1*0303。基于对PMR和IDDM都有HLA易感性，她似乎在年轻时就患上了这些疾病。
