Anderson A H, Warady B A, Daily D K, Johnson J A, Thomas M K
Children's Mercy Hospital, University of Missouri-Kansas City School of Medicine.
Am J Perinatol. 1993 May;10(3):190-3. doi: 10.1055/s-2007-994716.
The clinical course of 87 infants with bronchopulmonary dysplasia (BPD) on home oxygen therapy was reviewed to determine the occurrence of systemic hypertension (HTN) and to evaluate associated clinical features. Eleven of 87 (13%) infants developed systemic HTN either in the neonatal intensive care unit or following discharge. Clinical features that distinguished the hypertensive from the normotensive group were as follows: greater use of bronchodilators, 91% vs 37% (p < 0.001), and diuretics, 91% vs 55% (p < 0.05), longer duration of home oxygen therapy 21.6 +/- 9.9 vs 9.2 +/- 5.8 months (p < 0.05), and greater mortality, 36% vs 1% (p < 0.001). The course of systemic HTN in the surviving patients (7 of 11) was benign and resolved in all patients prior to weaning from home oxygen therapy. Systemic HTN is frequently present in infants with severe BPD and appears to be related to the clinical severity of lung disease.
回顾了87例接受家庭氧疗的支气管肺发育不良（BPD）婴儿的临床病程，以确定系统性高血压（HTN）的发生率并评估相关临床特征。87例婴儿中有11例（13%）在新生儿重症监护病房或出院后出现系统性HTN。高血压组与血压正常组的临床特征如下：支气管扩张剂使用更多，分别为91%和37%（p<0.001）；利尿剂使用更多，分别为91%和55%（p<0.05）；家庭氧疗持续时间更长，分别为21.6±9.9个月和9.2±5.8个月（p<0.05）；死亡率更高，分别为36%和1%（p<0.001）。存活患者（11例中的7例）的系统性HTN病程呈良性，所有患者在停止家庭氧疗前均已缓解。系统性HTN在重度BPD婴儿中经常出现，似乎与肺部疾病的临床严重程度有关。
