Fellenberg A J, Pollard A C
Clin Chim Acta. 1976 Jun 15;69(3):429-31. doi: 10.1016/0009-8981(76)90115-7.
Carbamazepine and 5,5-diphenylhydantoin are simultaneously extracted from 100-200 mul blood with 1,2-dichloroethane. 5,5-Diphenylhydantoin is removed by a one-step wash into alkali. The dichloroethane is further washed with acid and then evaporated to dryness. 5,5-Diphenylhydantoin is determined in the alkali washing by a benzophenone procedure; carbamazepine is determined in the dried residue by the 9-methylacridine procedure earlier described. The combined method is rapid, reliable and has a detection threshold of less than 0.1 mg/100 ml for each drug.
卡马西平和5,5-二苯基乙内酰脲用1,2-二氯乙烷从100 - 200微升血液中同时萃取。通过一步碱洗除去5,5-二苯基乙内酰脲。二氯乙烷再用酸洗，然后蒸发至干。5,5-二苯基乙内酰脲在碱洗液中用二苯甲酮法测定；卡马西平在干燥残渣中用前述的9-甲基吖啶法测定。该联合方法快速、可靠，每种药物的检测限均低于0.1毫克/100毫升。
