1例急性麻疹脑炎患者脑脊液中寡克隆免疫球蛋白和麻疹病毒抗体的短暂出现
Transient appearance of oligoclonal immunoglobulins and measles virus antibodies in the cerebrospinal fluid in a case of acute measles encephalitis.
作者信息
Sköldenberg B, Carlström A, Forsgren M, Norrby E
出版信息
Clin Exp Immunol. 1976 Mar;23(3):451-5.
Abstract
Acute measles encephalitis with severe sequelae in a 25-year-old man was studied. A transient appearance of oligoclonal IgG in cerebrospinal fluid and of intrathecally produced measles antibodies was found during 2 months after the onset of the disease. On the basis of this finding of local hyperimmunization it is proposed that in the case studied the measles virus infection may have been directly responsible for the disease process in the central nervous system.
摘要
对一名患有严重后遗症的25岁男性急性麻疹脑炎进行了研究。在疾病发作后的2个月内，发现脑脊液中短暂出现寡克隆IgG以及鞘内产生的麻疹抗体。基于这种局部超免疫的发现，有人提出在所研究的病例中，麻疹病毒感染可能直接导致了中枢神经系统的疾病进程。
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本文引用的文献
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[Comparative studies of quantitative determination of proteins in cerebrospinal fluid and low-protein solutions].[脑脊液和低蛋白溶液中蛋白质定量测定的比较研究]
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Isolation of measles virus from cell cultures of brain from a patient with subacute sclerosing panencephalitis.从一名亚急性硬化性全脑炎患者的脑的细胞培养物中分离出麻疹病毒。
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Immunoglobulins and measles antibodies in subacute sclerosing panencephalitis.亚急性硬化性全脑炎中的免疫球蛋白和麻疹抗体
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Identification of different measles virus-specific antibodies in the serum and cerebrospinal fluid from patients with subacute sclerosing pancencephalitis and multiple sclerosis.亚急性硬化性全脑炎和多发性硬化症患者血清及脑脊液中不同麻疹病毒特异性抗体的鉴定
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