Lakshminarayan S, Sahn S A, Hudson L D, Weil J V
Clin Pharmacol Ther. 1976 Aug;20(2):178-83. doi: 10.1002/cpt1976202178.
To investigate the effects of diazepam on ventilatroy control, hypoxic and hypercapnic ventilatory responses were studied in 8 normal subjects before and after 10 mg of intramuscular diazepam. There was no significant change in either resting minute ventilation or resting end-tidal CO2 tension, but depression of hypoxic ventilatory response was observed 15 (60% of control) and 30 min (53% of control) after diazepam (p less than 0.05). No significant depression of hypercapnic ventilatory response was noted 70 to 130 min after diazepam. In view of the depression of hypoxic ventilatory response by diazepam in normal subjects, adverse responses along these lines should be considered in patients with impaired ventilatory function, such as chronic airways obstruction, and in those encountering acute hypoxemia.
为研究地西泮对通气控制的影响，在8名正常受试者肌肉注射10毫克地西泮前后，对其低氧和高碳酸通气反应进行了研究。静息分钟通气量或静息呼气末二氧化碳分压均无显著变化，但地西泮注射后15分钟（为对照值的60%）和30分钟（为对照值的53%）观察到低氧通气反应受到抑制（p小于0.05）。地西泮注射后70至130分钟，未观察到高碳酸通气反应有显著抑制。鉴于地西泮可抑制正常受试者的低氧通气反应，对于通气功能受损的患者，如慢性气道阻塞患者以及遭遇急性低氧血症的患者，应考虑此类不良反应。
