Calverley P M, Carmichael G L, Scott D B
Br J Clin Pharmacol. 1984 Aug;18(2):163-7. doi: 10.1111/j.1365-2125.1984.tb02448.x.
We have studied the effects of chlormethiazole infusion on the ventilatory response to progressive isocapnic hypoxia in seven healthy volunteers, during both normocapnia and induced hypercapnia. The dose of chlormethiazole was such that it produced the same degree of hypnosis as would be expected from oral administration of two capsules each containing 192 mg of base in arachis oil. Ventilation did not change significantly during chlormethiazole administration. The ventilatory response to hypoxia was unaffected by chlormethiazole during normocapnia and was enhanced during hypercapnia. In these subjects, giving chlormethiazole intravenously was not associated with depression of the resting ventilation nor the hypoxia ventilatory response.
我们研究了在七名健康志愿者中，在正常碳酸血症和诱导性高碳酸血症期间，输注氯美噻唑对渐进性等碳酸血症性低氧通气反应的影响。氯美噻唑的剂量产生的催眠程度与口服两粒各含192毫克油剂基质的胶囊预期产生的催眠程度相同。在输注氯美噻唑期间，通气没有显著变化。在正常碳酸血症期间，氯美噻唑对低氧的通气反应未受影响，而在高碳酸血症期间则增强。在这些受试者中，静脉给予氯美噻唑与静息通气或低氧通气反应的抑制无关。
