BTA检测在膀胱癌中的意义：一项多中心试验。日本BTA研究组
Significance of the BTA test in bladder cancer: a multicenter trial. BTA Study Group Japan.
作者信息
Miyanaga N, Akaza H, Kameyama S, Hachiya T, Ozono S, Kuroda M, Koga H, Koiso K
机构信息
Department of Urology, University of Tsukuba, Japan.
出版信息
Int J Urol. 1997 Nov;4(6):557-60. doi: 10.1111/j.1442-2042.1997.tb00308.x.
BACKGROUND
The BTA test is a latex agglutination assay for the qualitative detection in the urine of analytes that are associated with bladder tumor. We compared the results of the BTA test with those of voided urine cytology (VUC) in patients with bladder cancer.
METHODS
A multicenter trial was performed at 6 institutions. A total of 132 patients with histologically diagnosed bladder cancer were enrolled. Urine samples were split for BTA and VUC testing.
RESULTS
The sensitivities of the BTA test and VUC were 57.6% and 37.9%, respectively; this difference was significant (P < 0.001). The BTA test had much higher sensitivity for small, solitary, superficial tumors than did VUC.
CONCLUSION
The BTA test is simple to perform, gives rapid results, and is far more sensitive than VUC for detection of bladder cancer. The BTA test has the potential to become an additional tool for detecting bladder cancer.
背景
BTA检测是一种乳胶凝集试验，用于定性检测尿液中与膀胱肿瘤相关的分析物。我们比较了膀胱癌患者BTA检测结果与晨尿细胞学检查（VUC）结果。
方法
在6家机构进行了一项多中心试验。共纳入132例经组织学诊断为膀胱癌的患者。将尿液样本分为两份分别进行BTA检测和VUC检测。
结果
BTA检测和VUC的敏感性分别为57.6%和37.9%；差异有统计学意义（P<0.001）。BTA检测对小的、孤立的、浅表性肿瘤的敏感性远高于VUC。
结论
BTA检测操作简单、结果快速，在检测膀胱癌方面远比VUC敏感。BTA检测有可能成为检测膀胱癌的辅助工具。
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