Bartholomé K, Geiger H, Schimpf K
Dtsch Med Wochenschr. 1976 Aug 20;101(34):1252-4. doi: 10.1055/s-0028-1104251.
Two nine-year-old boys with haemophilia A and circulating inhibitor against factor VIII were given large doses of commercial AHG concentrates to control bleeding. But the isoagglutinins in the AHG concentrates caused haemolysis in both patients. When AHF (Immuno) from AB donors - a cryoprecipate without isoagglutinins - was used no further inhibitor activity was detectable, previously observed anaphylactoid reactions no longer occurred and usual doses of AHG were now sufficient to control bleeding.
两名患有甲型血友病且体内存在抗凝血因子 VIII 循环抑制物的9岁男孩，接受了大剂量的商业抗血友病球蛋白（AHG）浓缩物以控制出血。但AHG浓缩物中的同种凝集素导致两名患者均发生了溶血。当使用来自AB型供血者的抗血友病因子（免疫）——一种不含同种凝集素的冷沉淀——时，未检测到进一步的抑制物活性，先前观察到的类过敏反应不再发生，并且常规剂量的AHG现在足以控制出血。
