甾体衍生物。LXXIX. 布氏小克银汉霉作用下孕甾烷系列17α-乙酰氧基-16-亚甲基衍生物的微生物15β-羟基化反应
Steroid derivatives. LXXIX. Microbial 15 beta-hydroxylation of 17 alpha-acetoxy-16-methylene derivatives of the pregnane series by the action of Cunninghamella blakesleeana.
作者信息
Mícková R, Protiva J, Schwarz V
出版信息
Folia Microbiol (Praha). 1976;21(2):144-51. doi: 10.1007/BF02876982.
PMID:947832
Abstract
Hydroxylation of 17 alpha-acetoxy-6-chloro-16-methylene-4,6-pregnadiene-3,20-dione (Chlorosuperlutin, I) by Cunninghamella blakesleeana yielded a 15 beta-hydroxyderivative II. Analogous transformation of 17 alpha-acetoxy-16-methylene-4,6-pregnadiene-3,20-dione (Superlutin, IV) included a hydroxylation in position 15 beta and probably also in 11 beta with a concomitant reduction of the 6,7-double bond.
摘要
布氏小克银汉霉对17α-乙酰氧基-6-氯-16-亚甲基-4,6-孕二烯-3,20-二酮（氯超卢替宁，I）的羟基化反应生成了一种15β-羟基衍生物II。17α-乙酰氧基-16-亚甲基-4,6-孕二烯-3,20-二酮（超卢替宁，IV）的类似转化包括在15β位的羟基化，可能还包括在11β位的羟基化，同时6,7-双键发生还原。
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