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甾体衍生物。LXXIX. 布氏小克银汉霉作用下孕甾烷系列17α-乙酰氧基-16-亚甲基衍生物的微生物15β-羟基化反应

Steroid derivatives. LXXIX. Microbial 15 beta-hydroxylation of 17 alpha-acetoxy-16-methylene derivatives of the pregnane series by the action of Cunninghamella blakesleeana.

作者信息

Mícková R, Protiva J, Schwarz V

出版信息

Folia Microbiol (Praha). 1976;21(2):144-51. doi: 10.1007/BF02876982.

DOI:10.1007/BF02876982
PMID:947832
Abstract

Hydroxylation of 17 alpha-acetoxy-6-chloro-16-methylene-4,6-pregnadiene-3,20-dione (Chlorosuperlutin, I) by Cunninghamella blakesleeana yielded a 15 beta-hydroxyderivative II. Analogous transformation of 17 alpha-acetoxy-16-methylene-4,6-pregnadiene-3,20-dione (Superlutin, IV) included a hydroxylation in position 15 beta and probably also in 11 beta with a concomitant reduction of the 6,7-double bond.

摘要

布氏小克银汉霉对17α-乙酰氧基-6-氯-16-亚甲基-4,6-孕二烯-3,20-二酮（氯超卢替宁，I）的羟基化反应生成了一种15β-羟基衍生物II。17α-乙酰氧基-16-亚甲基-4,6-孕二烯-3,20-二酮（超卢替宁，IV）的类似转化包括在15β位的羟基化，可能还包括在11β位的羟基化，同时6,7-双键发生还原。

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本文引用的文献

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SUBSTRATE SPECIFICITY IN STEROID SIDE-CHAIN DEGRADATION BY MICROORGANISMS.
Biochim Biophys Acta. 1964 Nov 8;93:411-7. doi: 10.1016/0304-4165(64)90393-9.
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[STUDIES IN THE FIELD OF MICROBIOLOGICAL TRANSFORMATIONS. XX. HYDROXYLATION OF PROGESTERONE BY SYNCEPHALASTRUM RACEMOSUM COHN (5)].微生物转化领域的研究。二十。总状毛霉（Syncephalastrum racemosum Cohn）对孕酮的羟基化作用（5）
Chem Pharm Bull (Tokyo). 1963 Dec;11:1579-85. doi: 10.1248/cpb.11.1579.
3
Microbial transformation of steroids. XVII. Transformation of progesterone by various species and strains of Penicillium.甾体的微生物转化。十七。不同青霉菌种和菌株对孕酮的转化
Folia Microbiol (Praha). 1962 Mar;7:121-5. doi: 10.1007/BF02927235.