Rouse D, Mackay P, Stirnberg P, Estelle M, Leyser O
Department of Biology, University of York, York YO1 5YW, UK.
Science. 1998 Feb 27;279(5355):1371-3. doi: 10.1126/science.279.5355.1371.
Transcription of the AUX/IAA family of genes is rapidly induced by the plant hormone auxin, but evidence that AUX/IAA genes mediate further responses to auxin has been elusive. Changes in diverse auxin responses result from mutations in the Arabidopsis AXR3 gene. AXR3 was shown to be a member of the AUX/IAA family, providing direct evidence that AUX/IAA genes are central in auxin signaling. Molecular characterization of axr3 gain-of-function and loss-of-function mutations established the functional importance of domains conserved among AUX/IAA proteins.
植物激素生长素能迅速诱导AUX/IAA基因家族的转录，但关于AUX/IAA基因介导对生长素进一步反应的证据一直难以捉摸。拟南芥AXR3基因突变会导致多种生长素反应发生变化。AXR3被证明是AUX/IAA家族的成员，这为AUX/IAA基因在生长素信号传导中起核心作用提供了直接证据。对axr3功能获得性和功能丧失性突变的分子特征分析确定了AUX/IAA蛋白中保守结构域的功能重要性。
