Solomon H M, Frist S
Neuromedical Systems, Inc., Suffern, New York 10901-4114, USA.
Acta Cytol. 1998 Jan-Feb;42(1):253-9. doi: 10.1159/000331554.
To define and evaluate the effectiveness of the PAPNET Testing System for high grade squamous cervical intraepithelial lesions (HSIL).
The literature was reviewed, defining the "few cell/small cell challenge" associated with HSIL. Several recently published investigations demonstrate the effectiveness of PAPNET testing, especially the effectiveness of PAPNET testing in reducing false negatives for these lesions.
The results of several independent investigations demonstrate that the PAPNET Testing System is sensitive to the types of abnormalities typically not detected by conventional screening (e.g., abnormal cells that are small and few in number). In clinical practice, the PAPNET Testing System is effective in reducing false negatives.
The PAPNET Testing System helps solve the "unfortunate paradox of Pap smear diagnosis," as noted by DeMay, that high grade serious lesions may be more difficult to detect and diagnose by cytology than low grade lesions, which are clinically less significant and often regress without therapy. The accuracy of detection of HSIL is improved with the PAPNET Testing System.
定义并评估PAPNET检测系统对高级别宫颈鳞状上皮内病变（HSIL）的有效性。
回顾文献，明确与HSIL相关的“少细胞/小细胞挑战”。近期发表的几项研究证明了PAPNET检测的有效性，尤其是PAPNET检测在减少这些病变假阴性方面的有效性。
几项独立研究的结果表明，PAPNET检测系统对传统筛查通常无法检测到的异常类型敏感（例如数量少且细胞小的异常细胞）。在临床实践中，PAPNET检测系统在减少假阴性方面有效。
正如德梅所指出的，PAPNET检测系统有助于解决“巴氏涂片诊断的不幸悖论”，即与临床意义较小且通常无需治疗即可消退的低级别病变相比，高级别严重病变通过细胞学检测可能更难发现和诊断。PAPNET检测系统提高了HSIL的检测准确性。
