Farnsworth A, Chambers F M, Goldschmidt C S
Med J Aust. 1996 Oct 21;165(8):429-31.
To compare the results of an automated rescreening device (PAPNET) with manual screening of Papanicolaou (Pap) smears.
All normal or technically unsatisfactory smears and a random sample of abnormal smears on manual screening were submitted for PAPNET rescreening.
Large general pathology laboratory in Sydney between January and September 1995.
Of 54,658 PAP smears classified on manual screening as normal 266 were reclassified as abnormal after PAPNET screening (32 atypical squamous cells of uncertain significance, 217 low-grade squamous intraepithelial lesions and 17 high-grade intraepithelial lesions). Of the random sample of 1022 smears classified on manual screening as abnormal, all high-grade intraepithelial lesions (122 smears) and squamous cell carcinomas (2 smears) were also detected by PAPNET, and 112 were reclassified as normal by PAPNET (14 atypical squamous cells of uncertain significance and 98 low-grade squamous intraepithelial lesions). Histological follow-up confirmed 15 of the 17 smears classified as high-grade intraepithelial lesions on PAPNET screening and detected a further seven that had been classified by PAPNET as either atypical squamous cells of uncertain significance or low-grade squamous intraepithelial lesions.
When used as a quality-control measure in a general pathology laboratory, the PAPNET automated screening system detects higher numbers of abnormal PAP smears than manual screening.
比较自动复查设备（PAPNET）与巴氏涂片手动筛查的结果。
所有手动筛查为正常或技术上不合格的涂片以及手动筛查为异常涂片的随机样本均提交给PAPNET进行复查。
1995年1月至9月悉尼的大型普通病理实验室。
在手动筛查分类为正常的54658份巴氏涂片中，PAPNET筛查后有266份被重新分类为异常（32例意义不明确的非典型鳞状细胞、217例低级别鳞状上皮内病变和17例高级别上皮内病变）。在手动筛查分类为异常的1022份涂片随机样本中，PAPNET也检测出了所有高级别上皮内病变（122份涂片）和鳞状细胞癌（2份涂片），并且有112份被PAPNET重新分类为正常（14例意义不明确的非典型鳞状细胞和98例低级别鳞状上皮内病变）。组织学随访证实了PAPNET筛查中分类为高级别上皮内病变的17份涂片中的15份，并检测出另外7份被PAPNET分类为意义不明确的非典型鳞状细胞或低级别鳞状上皮内病变的涂片。
在普通病理实验室用作质量控制措施时，PAPNET自动筛查系统比手动筛查能检测出更多异常巴氏涂片。
