19-羟基-Δ4-雄烯-3,17-二酮在循环中的Δ4-雄烯-3,17-二酮转化为雌酮过程中的作用。

The role of 19-hydroxy-delta4-androstene-3,17-dione in the conversion of circulating delta4-androstene-3, 17-dione to estrone.

作者信息

Kelly W G, De Leon O, Rizkallah T H

出版信息

J Clin Endocrinol Metab. 1976 Jul;43(1):190-4. doi: 10.1210/jcem-43-1-190.

Abstract

A mixture of 4-14C-delta4-androstene-3, 17-dione and 6,7-3 H-19-hydroxy-delta4-androstene-3, 17-dione was intravenously injected into three women, and the 3H/14C ratios in urinary 19-hydroxyandrostenedione and urinary estrogens were determined. The ratios of 3H/14C in the estrogens were similar to those of the dose, while the ratios in urinary 19-hydroxyandrostenedione were mcuh higher than those of the dose. The fractional conversions of androstenedione to estrone and of 19-hydroxyandrostenedione to estrone are therefore similar. However, little, if any, 19-hydroxyandrostenedione produced during aromatization enters the circulation and mixes with injected 19-hydroxyandrostenedione.

摘要

将4-¹⁴C-δ⁴-雄烯-3,17-二酮和6,7-³H-19-羟基-δ⁴-雄烯-3,17-二酮的混合物静脉注射到三名女性体内，然后测定尿中19-羟基雄烯二酮和尿雌激素中的³H/¹⁴C比值。雌激素中的³H/¹⁴C比值与剂量中的比值相似，而尿中19-羟基雄烯二酮的比值则远高于剂量中的比值。因此，雄烯二酮向雌酮的分数转化率以及19-羟基雄烯二酮向雌酮的分数转化率相似。然而，芳香化过程中产生的19-羟基雄烯二酮即使有也很少进入循环系统并与注射的19-羟基雄烯二酮混合。