Kaliner M
J Allergy Clin Immunol. 1976 Aug;58(2):308-15. doi: 10.1016/0091-6749(76)90136-6.
The cholinergically innervated human eccrine sweat gland is a readily available organ permitting the assessment in allergic patients of cholinergic reactivity with few or no adrenergic influences. The sweat responses of four matched groups (male allergic, female allergic, male control, and female control) to intradermal Mecholyl from 0.1 mug to 100 mug was compared; the 45 male and 45 female allergic patients demonstrated statistically significant increases in sweat responses to essentially all concentrations of Mecholyl examined. No difference in the sweat responses of patients with allergic rhinitis alone was compared with patients with both allergic rhinitis and allergic asthma was noted. Five patients with intrinsic asthma most closely resembled the allergic groups in their responses and 8 patients with vasomotor rhinitis sweated at or below the control groups. The increased sensitivity of allergic patients to cholinergic stimulation as measured by eccrine sweat responses suggest that this hyperresponsiveness may be one of the underlying defects in allergic disease.
胆碱能神经支配的人体小汗腺是一个易于获取的器官，可用于评估过敏患者的胆碱能反应性，且几乎没有或不存在肾上腺素能影响。比较了四组匹配人群（男性过敏者、女性过敏者、男性对照者和女性对照者）对皮内注射0.1微克至100微克乙酰甲胆碱的汗液反应；45名男性和45名女性过敏患者对几乎所有检测浓度的乙酰甲胆碱的汗液反应均有统计学意义的增加。单独患有过敏性鼻炎的患者与同时患有过敏性鼻炎和过敏性哮喘的患者的汗液反应没有差异。5名内源性哮喘患者的反应与过敏组最为相似，8名血管运动性鼻炎患者的出汗量与对照组相当或低于对照组。通过小汗腺汗液反应测量的过敏患者对胆碱能刺激的敏感性增加表明，这种高反应性可能是过敏性疾病的潜在缺陷之一。
