中国无偿献血者中庚型肝炎病毒感染情况
Hepatitis G virus infection in screened Chinese blood donors.
作者信息
Ren F R, Wang Y, Li H, Chen H S, Zhao H Y
机构信息
Beijing Red Cross Blood Center, China.
出版信息
Vox Sang. 1998;74(1):51-2.
BACKGROUND AND OBJECTIVES
To determine the prevalence of the recently identified hepatitis G virus (HGV)/GBV-C in screened Chinese paid blood donors.
MATERIALS AND METHODS
Two hundred and seventy-nine plasma samples were tested for HGV RNA by RT-PCR with nested primers from the 5'-noncoding region of GBV-C. All samples were obtained from plasma or blood bags that had been screened twice by routine selection tests (ALT, HBsAg, Anti-HCV, anti-HIV, and syphilis) and were available for clinical use.
RESULTS
HGV RNA was detected in 2 (4%) of 50 paid plasma donors from the Beijing Red Cross Blood Center, 1 (2%) of 50 paid blood donors from Taiyuan, and 9 (5%) of 179 paid blood donors from Hebei, a total HGV detection rate of 4.3% (12/279).
CONCLUSIONS
Our data suggest that HGV infection is relatively frequent even in screened donors, at least in paid screened donors, although larger-scale studies are required.
背景与目的
确定在经筛查的中国有偿献血者中最近发现的庚型肝炎病毒（HGV）/GBV-C的流行情况。
材料与方法
采用针对GBV-C 5'-非编码区的巢式引物，通过逆转录聚合酶链反应（RT-PCR）对279份血浆样本进行HGV RNA检测。所有样本均取自经常规筛选试验（丙氨酸转氨酶、乙肝表面抗原、抗丙型肝炎病毒、抗人类免疫缺陷病毒和梅毒）两次筛查且可供临床使用的血浆或血袋。
结果
在北京红十字血液中心的50名有偿血浆捐献者中，2人（4%）检测出HGV RNA；在太原的50名有偿献血者中，1人（2%）检测出HGV RNA；在河北的179名有偿献血者中，9人（5%）检测出HGV RNA，HGV总检出率为4.3%（12/279）。
结论
我们的数据表明，即使在经筛查的献血者中，HGV感染也相对常见，至少在经筛查的有偿献血者中如此，尽管还需要开展更大规模的研究。
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