Daskalogiannakis J, Kuntz K L, Chudley A E, Ross R B
Division of Orthodontics, The Hospital for Sick Children, Toronto, Ontario, Canada.
Cleft Palate Craniofac J. 1998 Jan;35(1):46-51. doi: 10.1597/1545-1569_1998_035_0046_uclwow_2.3.co_2.
The purpose of this study was to investigate the possibility of a relationship between the side of occurrence of unilateral clefting of the lip and/or palate and handedness, also taking into account the type of the initial cleft condition, a factor that has not been adequately assessed in previous studies.
This was a retrospective study.
Division of Orthodontics, The Hospital for Sick Children, Toronto, Canada, and Cleft Lip and Palate Program, Children's Hospital, Winnipeg, Canada.
Subjects were 289 patients (176 males and 113 females) 9 years of age or older presenting with a history of unilateral clefts of the lip with or without the palate. Of these patients, 217 were recruited from the patient pool of the Orthodontic Clinic at the Hospital for Sick Children in Toronto. The remaining 72 were selected from the registry of the Cleft Lip and Palate Program of the Children's Hospital in Winnipeg. Any syndromic cases were excluded from the sample.
Assessment of handedness was performed by asking the patients to fill out a multi-item questionnaire in which patients were asked to identify which hand they would use for different tasks. The side and type of the initial cleft condition were identified by reviewing each patient's hospital chart and by cross-referencing with clinical examination. Statistical evaluation of the results was performed by using the chi-square test.
There was a significantly larger number of left-sided clefts (198) in the sample than right-sided clefts (91), (p < .001). The proportion of left-sided clefts among left-handers (84.6%) was higher than that among right-handers (66.8%). However, the relationship between side of cleft and handedness was not statistically significant (p = .185). Clefts of the primary palate only seemed to occur on the left side 3.5 times more often than on the right, whereas the corresponding ratio of left:right manifestation for clefts of the primary and secondary palate was 1.8:1. The difference was statistically significant (p < .05).
The findings of this study confirm the affinity of unilateral clefts for the left side but suggest that there are differences between clefts of the primary palate only and clefts of the primary and secondary palate. Also, non-right-handed patients show a greater predilection for having a cleft on the left side than do right-handed patients.
本研究旨在探讨唇裂和/或腭裂单侧发生的部位与利手之间存在关联的可能性，同时考虑初始腭裂情况的类型，这一因素在以往研究中未得到充分评估。
这是一项回顾性研究。
加拿大多伦多病童医院正畸科以及加拿大温尼伯儿童医院唇腭裂项目组。
研究对象为289例9岁及以上有单侧唇裂病史（伴或不伴腭裂）的患者（176例男性和113例女性）。其中，217例患者从加拿大多伦多病童医院正畸诊所的患者库中招募。其余72例从加拿大温尼伯儿童医院唇腭裂项目组的登记处选取。样本中排除了所有综合征病例。
通过让患者填写一份多项问卷来评估利手情况，问卷中要求患者指明在不同任务中会使用哪只手。通过查阅每位患者的医院病历并结合临床检查来确定初始腭裂情况的部位和类型。使用卡方检验对结果进行统计学评估。
样本中左侧腭裂（198例）的数量显著多于右侧腭裂（91例），（p < .001）。左利手患者中左侧腭裂的比例（84.6%）高于右利手患者（66.8%）。然而，腭裂部位与利手之间的关系无统计学意义（p = .185）。仅原发腭部的腭裂似乎发生在左侧的频率比右侧高3.5倍，而原发腭和继发腭部腭裂的左右侧表现对应比例为1.8:1。差异具有统计学意义（p < .05）。
本研究结果证实了单侧腭裂对左侧的偏好，但表明仅原发腭部的腭裂与原发腭和继发腭部的腭裂之间存在差异。此外，非右利手患者比右利手患者更倾向于左侧发生腭裂。
