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本文引用的文献

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[Clinical-epidemiological study in children with cleft lip palate in a secondary-level hospital].[二级医院唇腭裂患儿的临床流行病学研究]
Bol Med Hosp Infant Mex. 2017 Mar-Apr;74(2):107-121. doi: 10.1016/j.bmhimx.2016.11.008. Epub 2017 Mar 18.
2
Cleft lip - a comprehensive review.唇裂 - 全面综述。
Front Pediatr. 2013 Dec 27;1:53. doi: 10.3389/fped.2013.00053.
3
Frequency of cleft lip and palate among live births in Akbar Abadi Hospital.阿克巴阿巴迪医院活产儿中唇腭裂的发生率。
Acta Med Iran. 2012;50(10):704-6.
4
Roles of BMP signaling pathway in lip and palate development.骨形态发生蛋白信号通路在唇腭裂发育中的作用。
Front Oral Biol. 2012;16:60-70. doi: 10.1159/000337617. Epub 2012 Jun 25.
5
Epidemiology of oral clefts 2012: an international perspective.2012年口腔颌面部裂隙的流行病学:国际视角
Front Oral Biol. 2012;16:1-18. doi: 10.1159/000337464. Epub 2012 Jun 25.
6
A clinical and demographic profile of the cleft lip and palate in Sub-Himalayan India: A hospital-based study.印度喜马拉雅山地区唇腭裂的临床和人口统计学特征:一项基于医院的研究。
Indian J Plast Surg. 2012 Jan;45(1):115-20. doi: 10.4103/0970-0358.96602.
7
The evolution of human genetic studies of cleft lip and cleft palate.唇腭裂的人类遗传学研究进展。
Annu Rev Genomics Hum Genet. 2012;13:263-83. doi: 10.1146/annurev-genom-090711-163729. Epub 2012 Jun 6.
8
Epidemiological Analysis of Cleft Lip and/or Palate by Cleft Pattern.唇腭裂按裂隙类型的流行病学分析
J Maxillofac Oral Surg. 2010 Dec;9(4):389-95. doi: 10.1007/s12663-010-0132-6. Epub 2011 Mar 11.
9
Epidemiological aspects of cleft lip and palate in Iran.伊朗唇腭裂的流行病学特征
Acta Med Iran. 2011;49(1):54-8.
10
Cleft lip and palate: understanding genetic and environmental influences.唇腭裂:了解遗传和环境的影响。
Nat Rev Genet. 2011 Mar;12(3):167-78. doi: 10.1038/nrg2933.

2006 - 2019年秘鲁唇腭裂患者的临床和流行病学概况

Clinical and epidemiological profile of cleft lip and palate patients in Peru, 2006 - 2019.

作者信息

Peña-Soto Claudio, Arriola-Guillén Luis-Ernesto, Díaz-Suyo Antonio, Flores-Fraile Javier

机构信息

PhD, Associate Professor of Faculty of Sciences of Life and Health, School of Dentistry, Universidad Científica del Sur, Lima, Peru.

PhD, Associate Professor Division of Orthodontics, School of Dentistry, Universidad Científica del Sur, Lima, Peru.

出版信息

J Clin Exp Dent. 2021 Nov 1;13(11):e1118-e1123. doi: 10.4317/jced.58976. eCollection 2021 Nov.

DOI:10.4317/jced.58976
PMID:34824698
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8601701/
Abstract

BACKGROUND

The purpose of this study was to determine the clinical-epidemiological profile of patients with cleft lip and / or palate in Peru from 2006 to 2019.

MATERIAL AND METHODS

This retrospective and cross-sectional study analyzed 3,923 patients with cleft lip and palate attended by surgical missions of the Operación Sonrisa Perú from January 2006 to December 2019. The clinical profile of the patients treated included: type of cleft (cleft lip CL, cleft palate CP, cleft lip and palate CLP and submucosal SM), surgery performed (cheiloplasty, palatoplasty, cleft rhinoplasty, fistula repair, pharyngeal flap), surgical time according to number of interventions. Likewise, affiliation variables such as sex, age and birthplace were recorded. Descriptive analysis was performed. Associations were determined using the Pearson's Chi-square test and Two-sample test of proportions were used for comparing the percentages during time. A value <0.005 was considered significant.

RESULTS

The most frequent diagnosis was CP (n = 1411, 35.97%). We identified a statistically significant association between the diagnosis of CL, CP and gender ( = 0.045), being more prevalent in males. A higher prevalence of CL was also observed on the left side and in males (n = 183). Cheiloplasty was the most frequent first surgical intervention performed (n = 837, 47.42%) followed by fistula repair as the second intervention (n = 428, 42.29%).

CONCLUSIONS

Cleft lip and palate are more frequent in males, with CP being the most frequent. CL is more frequent on the left side and the first surgical approach in these patients is lip closure. Epidemiology, cleft lip and palate, surgical missions.

摘要

背景

本研究的目的是确定2006年至2019年秘鲁唇腭裂患者的临床流行病学特征。

材料与方法

这项回顾性横断面研究分析了2006年1月至2019年12月期间由秘鲁微笑行动外科医疗队诊治的3923例唇腭裂患者。所治疗患者的临床特征包括:腭裂类型(唇裂CL、腭裂CP、唇腭裂CLP和黏膜下腭裂SM)、所进行的手术(唇成形术、腭裂修复术、鼻唇裂修复术、瘘管修复术、咽瓣手术)、根据干预次数确定的手术时间。同样,记录了性别、年龄和出生地等相关变量。进行了描述性分析。使用Pearson卡方检验确定关联性,并使用两样本比例检验比较不同时期的百分比。P值<0.005被认为具有统计学意义。

结果

最常见的诊断是CP(n = 1411,35.97%)。我们发现CL、CP诊断与性别之间存在统计学显著关联(P = 0.045),在男性中更为普遍。左侧和男性中CL的患病率也较高(n = 183)。唇成形术是最常进行的首次手术干预(n = 837,47.42%),其次是瘘管修复术作为第二次干预(n = 428,42.29%)。

结论

唇腭裂在男性中更为常见,其中CP最为常见。CL在左侧更为常见,这些患者的首次手术方法是唇闭合。流行病学、唇腭裂、外科医疗队。