Prasad M R, Lovell M A, Yatin M, Dhillon H, Markesbery W R
Department of Surgery, University of Kentucky, Lexington 40536-0084, USA.
Neurochem Res. 1998 Jan;23(1):81-8. doi: 10.1023/a:1022457605436.
Regional levels of membrane phospholipids [phosphatidylethanolamine (PE), phosphatidylinositol (PI), phosphatidylcholine (PC)] were measured in the brain of Alzheimer's disease (AD) and control subjects. The levels of PE-derived and PI-derived total fatty acids were significantly decreased in the hippocampus of AD subjects. Here significant decreases were found in PE-derived stearic, oleic and arachidonic and docosahexaenoic acids, and in PI-derived oleic and arachidonic acids. In the inferior parietal lobule of AD subjects, significant decreases were found only in PE and those decreases were contributed by stearic, oleic and arachidonic acids. In the superior and middle temporal gyri and cerebellum of AD subjects, no significant decreases were found in PC-, PE- and PI-derived fatty acids. The decrease of PE and PI, which are rich in oxidizable arachidonic and docosahexaenoic acids, but not of PC, which contains lesser amounts of these fatty acids, suggests a role for oxidative stress in the increased degradation of brain phospholipids in AD.
在阿尔茨海默病（AD）患者和对照受试者的大脑中，对区域膜磷脂[磷脂酰乙醇胺（PE）、磷脂酰肌醇（PI）、磷脂酰胆碱（PC）]水平进行了测量。AD受试者海马体中PE衍生和PI衍生的总脂肪酸水平显著降低。在此，发现PE衍生的硬脂酸、油酸、花生四烯酸和二十二碳六烯酸以及PI衍生的油酸和花生四烯酸显著减少。在AD受试者的顶下小叶中，仅在PE中发现显著降低，且这些降低是由硬脂酸、油酸和花生四烯酸导致的。在AD受试者的颞上回和颞中回以及小脑中，未发现PC、PE和PI衍生脂肪酸有显著降低。富含可氧化花生四烯酸和二十二碳六烯酸的PE和PI减少，而含这些脂肪酸量较少的PC未减少，这表明氧化应激在AD患者脑磷脂降解增加中起作用。
