3-羟基-3-甲基戊二酸与 Triton 诱导的大鼠高脂血症
3-Hydroxy-3-methylglutaric acid and triton-induced hyperlipidemia in rats.
作者信息
Yousufzai S Y, Siddiqi M
出版信息
Experientia. 1976 Sep 15;32(9):1178-9. doi: 10.1007/BF01927612.
PMID:183980
Abstract
3-Hydroxy-3-methylglutaric acid (HMG) significantly decreased cholesterol, triglyceride and phospholipid levels in whole serum, serum beta-lipoproteins and liver of Triton-induced hyperlipidemic rats. Therapeutically 50 mg HMG/kg is equivalent to 200 mg nicotinic acid/kg in lowering all these lipid parameters. HMG may exert its hypolipidemic effect through inhibition of lipoprotein synthesis.
摘要
3-羟基-3-甲基戊二酸（HMG）可显著降低 Triton 诱导的高脂血症大鼠的全血清、血清β-脂蛋白和肝脏中的胆固醇、甘油三酯及磷脂水平。在治疗上，50mg HMG/kg 在降低所有这些脂质参数方面等同于 200mg 烟酸/kg。HMG 可能通过抑制脂蛋白合成发挥其降血脂作用。
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